STSM by Sylvain Maclot, CIMAP, Caen (FR) with Paola Bolognesi, CNR, IMIP (IT)
On March 26th, 2014 (12 days)


Study of stability of nucleosides and their radiosensitising analogues after interaction with X-Rays

This work is part of a combined effort of the groups at CIMAP in Caen and CNR/IMIP in Rome aiming to study the radiation damage of biomolecules at the molecular scale using X-ray absorption and multiply-charged ion impact.

The aim of the experiments performed in Elettra Synchrotron was to investigate the basic processes at molecular level occurring in nucleosides after interaction with X-Rays. Nucleosides are building blocks of DNA/RNA and are composed of a sugar and a nucleic base. This study was mainly focused on valence photoionization using photoemission spectroscopy (PES) and photo-electron-photo-ion coincidence (PEPICO) measurements in order to probe the fragmentation dynamics of ionised molecules. We obtained results for nucleosides 2’-deoxythymidine and 2’-deoxycytidine.

This work should lead to publication and especially marks the consolidation of collaboration between the two teams on nucleoside studies in the gas phase.


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